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8%-9% and 12%-13% hypoxic gas induced free radicals generation in rat^s left and right myocardium

Han Zhanyuan, Chen Ming, Wen Ping, Wang Qinghua

Physiological Laboratory of Hypoxia, Shanghai Institute of Physiology, Chinese Academy of Sciences. Shanghai 200031；China

Abstract

Alpha-phenyl-tert-butylnitrone (PBN) was administered intravenously to capture free radicals of rat^s myocardium. Rats were exposed to hypoxic gas (8%-9% O_(2) in N_(2) for 15min. The results suggested that one way of myocardium free radical gereration may be relevant to decrease of SOD activity. The generation of free radicals pertained chiefly to superoxide free radical in the left myocardium and the membrane structure of myocardium cells might have been damaged largely during hypoxia.

Key words: #alpha#-phenyl-tert-I-butylnirone;Superoxide dismutase;Free radicals; Myocardium;Malondialdehyde

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Citing This Article：

Han Zhanyuan, Chen Ming, Wen Ping, Wang Qinghua. 8%-9% and 12%-13% hypoxic gas induced free radicals generation in rat^s left and right myocardium. Acta Physiol Sin 1995; 47 (5): (in Chinese with English abstract).