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Effect of acute hypoxia on L-type calcium current of the ventricular myocytes of guinea-pig

Pan Shengjun, Zhou Zhaonian

Shanghai Institute of Physiology, Chinese Academy of Sciences. Shanghai 200031

Abstract

With nystatin-whole cell recording, the L-type calcum current after 10min acute hypoxia (Po_(2)4±0.7kPa) was inhibited (peak amplitude decreased) and the I-V relation was shifted upward. The inward calcium current showed no recovery after 10min reoxygenation. The peak amplitude was lower than that of the control. The results suggested that the decrease of action potential duration (APD) under acute hypoxia was not only due to increase of outward potassium current, but also to decrease of inward calcium current. All these phenomena may be related to some inhibition of phosphorylation of the L-type calcium channel in the cardiadc cells under hypoxia.

Key words: Free radicals;Cortex;Hippocampus;Hypoxia;#alpha#-phenyl-ter butylnitrone

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Citing This Article：

Pan Shengjun, Zhou Zhaonian. Effect of acute hypoxia on L-type calcium current of the ventricular myocytes of guinea-pig. Acta Physiol Sin 1995; 47 (5): (in Chinese with English abstract).