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Effects of lesion or stimulation of pituitary gland and hypothalamic arcuate nucleus on pain modulation in rats

Chen Qiliang, Li Jinhua, Zhou Zhijing, Yin Qizhang

Department of Physiology, Suzhou Medical College. Suzhou 215007,Jiangsu

Abstract

Relationship between pituitary gland and hypothalamic arcuate nucleus (ARC) in the modulation of pain threshold was investigated in Wistar rats with method of focal lesion and stimulation of pituitary gland. Experimental results indicated that electrolytic lesion of the pituitary intermediate and anterior lobes resulted in a decrease of pain threshold and disappearnce of the analgesia immediately produced by ARC stimulation. Stimulation of the same area of pituitary gland could induce a delayed analgesia, which could be blocked by ARC lesion.

Key words: Lesion;Stimulation;Pituitary gland;Hypothalamic arcuate nucleus;Pain threshold;Pain modulation

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Citing This Article：

Chen Qiliang, Li Jinhua, Zhou Zhijing, Yin Qizhang. Effects of lesion or stimulation of pituitary gland and hypothalamic arcuate nucleus on pain modulation in rats. Acta Physiol Sin 1995; 47 (5): (in Chinese with English abstract).