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Inhibitory effects of hypothalamic arcuate nucleus or anterior pituitary stimulation on the nociceptive responses of thalamic parafascicular neurons

Jiao Yongyi, Duanmu Zhaoxia, Yu Guangdi, Yin Qizhang

Laboratory of Neurobiology, Suzhou Medical College. Suzhou 215007, Jiangsu

Abstract

ARC stimulation could inhibit the nociceptive discharges of Pf neurons , namely, the immediate inhibition because of its very short latency and duration. AL stimulation could also inhibit the nociceptive discharges of Pf neurons, but this inhibition was a delayed one because of its longer latency and duration. Hypophysectiomy diminished the immediate inhibition due to ARC stimulation, while ARC lesion diminished the delayed inhibition due to AL stimulation. Both kinds of inhibition were blocked by dexamethasone pretreatment. The above results suggest that neuroendoerine relationship between ARC and AL is involved in pain modulation.

Key words: Hypothalamic arcuate nucleus;Pituitary;Thalamic parafascicular nucleus;Unit discharges;Dexamethasone;#beta#-endorphin;Analgesia

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Citing This Article：

Jiao Yongyi, Duanmu Zhaoxia, Yu Guangdi, Yin Qizhang. Inhibitory effects of hypothalamic arcuate nucleus or anterior pituitary stimulation on the nociceptive responses of thalamic parafascicular neurons. Acta Physiol Sin 1995; 47 (5): (in Chinese with English abstract).