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Hypoxia stimulates the expression of HSP70 in pulmonary artery smooth muscle cells

Feng Xiaodong, Cai Yingnian

Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences. Beijing 100005

Abstract

Hypoxic pulmonary hypertension is characterized by remodeling of pulmonary artery, proliferation and migration of pulmonary artery smooth muscle cells (PASMC), the mechanism of which was studied by observing the efeect of hypoxia on DNA synthesis, eell cycle phase and transcription of heat shock protein 70 (HSP70). Our results indicate that hypoxia increase DNA synthesis, enhances the mitogenic effect of ET-1 on PASMC, stimulates quiescent PASMC entering S phase from G_(0)/G_(1) phase and up-regulates the mRNA level of HSP70. Heat shock proteins are conservative and important stress proteins rendering the cells more tolerable to dangerous stresses by promoting growth and survival of the cells.

Key words: Hypoxia;Pulmonary artery smooth muscle cells;Proliferation;Heat shock protein 70

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Citing This Article：

Feng Xiaodong, Cai Yingnian. Hypoxia stimulates the expression of HSP70 in pulmonary artery smooth muscle cells. Acta Physiol Sin 1995; 47 (5): (in Chinese with English abstract).