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Inhibitory effect of interleukin-1#beta# on insulin release from isolated rat pancreatic islets and the reversal action of testosterone

Fang Haili, Wang Ling, Yang Yingkui, Zhu Wenyu

Department of Physiology, Beijing Medical University. Beijing 100083

Abstract

Insulin releaxse from pancreatic islet cells of neonatal rats could be markedly inhibited by a previous incubation of cells with interleukin--1#beta (5---20U/ml) for 20h even under high glucose (20mmol/L) stimulation. this inhibitory effect of IL--1#beta# on insulin release could be reversed by testosteron (10~(-10)mol/L), which was accompanied by an increase of the insulin content in islet cells.

Key words: Interleukin-1β;Insulin;Testosterone

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Citing This Article：

Fang Haili, Wang Ling, Yang Yingkui, Zhu Wenyu. Inhibitory effect of interleukin-1#beta# on insulin release from isolated rat pancreatic islets and the reversal action of testosterone. Acta Physiol Sin 1995; 47 (3): (in Chinese with English abstract).