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Effect of cholecystokinin and secretin on contractile activity of isolated gastric muscle strips in guinea pigs

Qu Songyi, Zheng Tianzhen, Li Wei

Department of Physiology, Lanzhou Medical College. Lanzhou 730000, Gansu

Abstract

Motility of gastric strips taken from different regions of guinea pig stomach were simultaneously recorded in 8 tissue chambers to test the effect of cholecystokinin--octapeptide (CCK--*) and secretin. It was found that CCK--8 could increase (1) all regional circular and longitudinal muscular tension at rest, (2) the frequency of contractions in body, antrum and pylorus (3)the mean contractole amplitude of antral circular strips, (4) the motility index of pylorus, but decrease the mean contractile amplitude of body and antral longitudinal strips. All the CCK--8 effects could not be blocked by atropine or indomethacin. Secretin was without effect on gastric smooth muscle activity.

Key words: Cholecystokinin-octapeptide (CCK-8);Secretin;Gasiric smooth muscle;Atropine;Indomethacin

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Citing This Article：

Qu Songyi, Zheng Tianzhen, Li Wei. Effect of cholecystokinin and secretin on contractile activity of isolated gastric muscle strips in guinea pigs. Acta Physiol Sin 1995; 47 (3): (in Chinese with English abstract).