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Effects of pentagastrin with intracerebro-ventricular injection on blood pressure and heart rate in rats

Wang Mingjiang, Huang Chengjun, Zhang Gongshou

Department of Physiology, Yunyang Medical College. Shiyan 442000, Hubei；China

Abstract

Experiments were carried out on 84 artifially ventilated SD rats anaesthetized with urethane and immobilized with gallamine triethiodide. Injection of pentagastrin (G_(5)) into the rat lateral ventride resulted in a marked elevation in arterial blood pressure which reached its peak at 3 min (from 12.2±1.5 to 14.1 ±1.7kPa) and also a significant increase in heart rate from 435±53.2 beats/min. This effect of G_(5)could be parially antagonized by injection of phentolaine (#alpha# antagonist, 10#mu#g) into the lateral ventricle, but not by propanolol (#beta receptor antagonist, 4#mu#g) or atropine (M--receptor antagonist, 4#mu#g). These findings indicate that the central effect of G_(5)on blood pressure and heart rate is partly mediated by #alpha#--receptor.

Key words: Pentagstrin;Intracerebro-ventricular;Blood pressure;Heart rate;Phentolamine

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Citing This Article：

Wang Mingjiang, Huang Chengjun, Zhang Gongshou. Effects of pentagastrin with intracerebro-ventricular injection on blood pressure and heart rate in rats. Acta Physiol Sin 1995; 47 (3): (in Chinese with English abstract).