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Different effect on L-glutamate microinjection into medial or lateral habenular nucleu on pain threshold

Zhao Hua, Wang Shao

Department of Physiology, Norman Bethune University of Medical Sciences. Changchun 130021, Jilin

Abstract

The habenulae (Hb) are related to modulation of pain sensation, but the results from different laboratories are inconsistant. The aim of the present investigation is to clarify the dicrepancy. L--Glutamic acid (L--Glu) was microinjected into medial (MHb) and lateral habenular nucleus (LHb) on light anesthetized or conscious rats, and pain threshold was then determined on the different models of animal The results showed that the activation of MHb increased TFL, whereas activation of LHb decreased TFL.

Key words: Habenulae;Tail-flick latency;Limbic system;L-Glutamic acid

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Citing This Article：

Zhao Hua, Wang Shao. Different effect on L-glutamate microinjection into medial or lateral habenular nucleu on pain threshold. Acta Physiol Sin 1995; 47 (3): (in Chinese with English abstract).