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Participation of dopamine of the muscarinergic inhibitory effect of substance P on gastric myoelectric activity and motility

Jing Hao, Lin Kunwei, Mei Maohua

Department of Physiology, Dalian Medical University. Dalian 116023, Liaoning

Abstract

Our previous study showed that microinjection of substance P (SP) into caudate nucleus inhibits gastric myoelectric fast wave and gastric motility, an effect mediated by muscarinic receptor. The present investigation showed that this effects of SP could be blocked by coinjected SP antiserum or SP antagonist [Arg~(6), D--Trip~(7,9), MePhe~(8)]--SP_(6-11)or D_(2)dopamine antagonist haloperidol. In addition, microinjection of dopamine (DA) into caudate nucleus could also inhibit gastric fast wave and motility, an effect again being blockable by coinjected DA antagonist haloperidol or atropine. Thus, it appears that the muscarinergic inhibitory effect of SP on gastric fast wave and motility is mediated by D_(2) dopamine receptor.

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Citing This Article：

Jing Hao, Lin Kunwei, Mei Maohua. Participation of dopamine of the muscarinergic inhibitory effect of substance P on gastric myoelectric activity and motility. Acta Physiol Sin 1995; 47 (2): (in Chinese with English abstract).