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The inhibitory effect and its mechanism of transferrin on FSH-induced diffferentiation of granulosa cells

Yu Jinghua, Guo Jian, Guo Jing, Zeng Fuxiang, Tang Guanghua

Department of Reproductive Physiology, Sichuan Family Planning Research Institute. Chengdu,Sichuan

Abstract

Trabsferrins are a class of related metal-binding transport glycoproteins for transporting iron to various organs and tissues of the body. In recent years, it has been reported that the transferrin can play an important role in the local regulation of ovarian function, apart from its iron-binding characteristic. Transferrin could attenuate FSH-induced differentiation of rat and human granulosa cells and its mechanisms were considered: Trabsferrins paritally blocked the binding of FSH with its receptors on granulosa cells and reduced the formation of intracellular cAMP, and therefore inhibited the expression of FSH receptors. Acting sites beyond cAMP formation also existed for the inhibitory effect of transferrin on hihibion and estradiol production. The inhibitory effect of transferrin seemed not to be involved in the changes of protein kinase C activity, the calcium release and “proliferation-differentiation reversed mechanism” in granulosa cells.

Key words: Transferrin;Granulosa cells;Differentiation;FSH;Estradioll;Progesterone; Inhibin

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Citing This Article：

Yu Jinghua, Guo Jian, Guo Jing, Zeng Fuxiang, Tang Guanghua. The inhibitory effect and its mechanism of transferrin on FSH-induced diffferentiation of granulosa cells. Acta Physiol Sin 1994; 46 (3): (in Chinese with English abstract).