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Effects of microiontophoretically applied GABA and 5-HT on the electric activities of neurons in nucleus parafascicularis of thalamus in rats

Zhang Lixin, Liu Zuoyan

Department of Physiology, Tongji Medical University. Wuhan,Hubei

Abstract

The effects of GABA and 5-HT on the electric activities of neurons of nucleus parafascicularis thalami (Pf)were observed in anesthetized rats with multimicropipete and iontophoresis and technique. Pain discharges of the Pf neurons were inhibited by microiontophoretically applied(MIA)GABA, an effect that could be reversed by MIA picrotoxin. Picrotoxin. Picrotoxin alone could enhance the pain discharges. The results indicate that GABA may be an inhibitory neurotransmitter responsible for the electric activities of Pf neurons. MIA 5-HT has both excitatory and inhibitory effects on the pain discharge of Pf neurons, while only the former could be blocked by MIA cyproteptadine.

Key words: Serotonin;GABA;Nucleus parafascicularis;Iontophoresis;Nociceptive discharges

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Citing This Article：

Zhang Lixin, Liu Zuoyan. Effects of microiontophoretically applied GABA and 5-HT on the electric activities of neurons in nucleus parafascicularis of thalamus in rats. Acta Physiol Sin 1994; 46 (3): (in Chinese with English abstract).