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Role of paraventriculo-spinal pathway in the inhibition of renal sympathetic nerve activity induced by blood volume expansion in rabbits

Qin Suli, Lin Maozhang

Department of Physiology, Dalian Medical College. Dalian,Li aoning

Abstract

In anesthetized and bilateral sinoaortic denervated rabbits with either intact or ascorbic acid injected paraventricular nucleus(PVN), the inhibition of renal sympathetic nerve activity(RSNA) induced by blood volume expansion (VE) all decreased by approximately 48%. However, 3—4h and 3—4d after kainic acid lesion of PVN, the inhibition of RSNA was attenuated respectively to —28.0±4.5% and —25.7±4.1%(P<0.05)with considerably shortened time course (P<0.01). Also such inhibition could be significantly attenuated(P<0.05)by intrathecal injection of vasopressinergic V_(1) receptor antagonist in spinal T_(10)—T_(12)segments. There was no significant difference with the slight and brief increase of mean arterial pressure induced by VE in the control and the experimental group. It was concluded that the inhibition of RSNA induced by VE is partly mediated by a vagal afferent triggered PVN-spinal pathway.

Key words: Paraventricular nucleus;Paraventriculo-spinal pathway;Blood volume expansion;Renal sympathetic nerve activity

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Citing This Article：

Qin Suli, Lin Maozhang. Role of paraventriculo-spinal pathway in the inhibition of renal sympathetic nerve activity induced by blood volume expansion in rabbits. Acta Physiol Sin 1994; 46 (3): (in Chinese with English abstract).