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Effect of agonists of opioid receptor on coronary arterial strips in porcine

Shi Ganggang, Wei Dongsheng, Xu Shaofen

Department of Neurobiology, Shanghai Medical University. Shanghai

Abstract

Selective agonist of K(U-50488H),u(ohmefentanyl OMF) and B(morphine and DADLE) receptor and wide spectrum agonist of opiod receptor etorphine all produced thew contraction of stripsdose-dependently. The order of the effect was U-50488H>morphine>etorphine >OMF, DADLE. Nalowone did not antagonize but increase the effect, or even produce contraction of the strips by itself. Haloperidol inhibited the contraction of fthe strip produed by U-50488H noncompetitively, also in a dose-dependent manner, probably without involving dopamine mechanism.

Key words: Coronary artery;Opioid receptor;Naloxone;Haloperidol

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Citing This Article：

Shi Ganggang, Wei Dongsheng, Xu Shaofen. Effect of agonists of opioid receptor on coronary arterial strips in porcine. Acta Physiol Sin 1994; 46 (2): (in Chinese with English abstract).