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Protective effect of tetrandrine on pancreatic islet cells damaged by alloxan in rats

Sun Guirong, Zhang Guifang, Wei Yingjie, Yang Diansheng, Zhang Jingxiang, Tian Zibin

Department of Physiology, Jiamusi Medical College. Jiamusi,Heilongjiang；China(200092)

Abstract

Tetrandrine injected intraperitoneally could prevent rats from diabetes induced by allowan. Immunohistochemical observation of islet B cells confirmed that TET couldd markedly prevent B cells from injuries induced by alloxan and there was no obvious change in the appearance of islet B cells in the preventive group . The results suggested that TET could protect pancreatic islet B cells from injuries caused by Alloxan.

Key words: Tetrandrine;Alloxan;Diabetes

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Citing This Article：

Sun Guirong, Zhang Guifang, Wei Yingjie, Yang Diansheng, Zhang Jingxiang, Tian Zibin. Protective effect of tetrandrine on pancreatic islet cells damaged by alloxan in rats. Acta Physiol Sin 1994; 46 (2): (in Chinese with English abstract).