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Cytoprotective effect of neurotensin on acetaminophen induced liver injury in relation to glutathione system

Li Jiyao, Wang Ling, Zhang Xijin

Department of Physiology, Beijing Medical University. Beijing

Abstract

Pretreatment with NT significantly reduced the leakages of transaminases induced by acetaminophen in vivo or in cultured hepatocytes and partially reversed the decline of DNA synthesis induced by acetaminophen in cultured hepatocytes.after sadministration of acetaminopohen to cultured hepoatocytes, the contents of reduced glutathione and total glutathione decreased, the activity of glutathione ne peroxydase decreased, but the contents of oxidized glutathione showed no change.Pretreatment with NT before acetaminophen decreased the contents of GSH further but increased the contents of GSSG and tota gultathione and enhanced the activity of GSH_Px.

Key words: Neurotensin;Acetaminophen;Hepatoprotection;Glutathione

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Citing This Article：

Li Jiyao, Wang Ling, Zhang Xijin. Cytoprotective effect of neurotensin on acetaminophen induced liver injury in relation to glutathione system. Acta Physiol Sin 1994; 46 (2): (in Chinese with English abstract).