Responses of motoneurons to ventrolateral funiculus stimulation in neonate rat spinal cord slices
Wang Mengya
Cell Electrophysiology Laboratory, Wannan Medical College. Wuhu,Anhui
Abstract
In more than 80% MNs, depolarization potentials with latency of 1.2±0.2 ms could be evoked by focal stimulaton of ventrolateral funiculus. when recorded at resting potential of -70±6mv, the time -to -peak, amplitde, half-decay time and duration of EPSPs to suprathreshold stimuli were respectively,2.6±0.4 ms, 13±8 ms.The EPSPs was observed in spite of varying stimulus frequency from 0.1 to5 Hz.Up on increasing stimuation requency>20Hz, EPSPs began to decrease and finally disappeared.In 3 MNs tested, the mean reversal potential of ESPs was -8mV.Loca/high Mg solution consistently attenuated but Mg-free solution enhanced the EPSPs.EPSPs were reversibly depressed by kynurenic acid and partially inhibited by ketamine.
Key words: Spianl cord;Motoneurons;Descending activation;Synaptic response;Glutamate
Received: Accepted:
Corresponding author: E-mail:
Citing This Article:
Wang Mengya. Responses of motoneurons to ventrolateral funiculus stimulation in neonate rat spinal cord slices. Acta Physiol Sin 1994; 46 (2): (in Chinese with English abstract).