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The effect of microinjection of AVP and AVP-antiserum into septal area on discharge activity of temperature-sensitive neurons in PO-AH of rabbits

Yang Yonglu, Chen Bangyong

Department of Physiology, Lanzhou Military Medical College of PLA. Lanzhou, Gansu

Abstract

aRGININE VASOPRESS IN (avp) HAS BEEN SHOWN TO HAVE SIGNICANT EFFECTS ON THERMOREGULATION. AVP-sensitive locus is located in the septal area of the limbic system. The present experiments were undertaken to investigate the effect of microinjecting AVP and AVP-antiserum into the septal area on the firing activity of temperature-sensitive neurons in preoptic-anterior hypothalams(PO-AH) of rabbit. The results were as follows: The firing rate of PO-AH warm-sensitivew and cold-sensitive neurons were respectively increased and decreased by injection AVP while that of temperature-insensitive neurons was unfaffected. Injection of AV=antiserum decreased the firing rate of PO-AH warm-sensitive neurons buyt increased the firing rate of cold-sensitive neurons. Injection of AVP increased the thermosensitivity of PO-AH warm-sensitive neurons and decreased the thermosensitivity of cold-sensitive neurons. The modulation action of AVP on PO-AH temperature-sensitive neurons was discussed.

Key words: Arginine vasopressin;AVP-antiserum;Unit discharge;Septal area;Temperature- tive-neuron;Thermosensitivity

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Citing This Article：

Yang Yonglu, Chen Bangyong. The effect of microinjection of AVP and AVP-antiserum into septal area on discharge activity of temperature-sensitive neurons in PO-AH of rabbits. Acta Physiol Sin 1994; 46 (2): (in Chinese with English abstract).