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The protective effects of metallothionein on membrane proteins against endothelin: electron paramagnetic resonance spin labelling study

Wang Gang, Hou Lin, Cheng Shi, Tang Chaoshu, An Rongshu

Dept. Biophys., Beijing Med. Univ.；Dept. Pathophysiol., Beijing Med. Univ.；Inst. Clin. Med., Chin-Japanese Friendship Hosp.

Abstract

The lipid fluidity in both of the polar region and the hydrophobic core in the membranes was not altered by endothelin at the concentration of 1×10~(-9), 1×10~(-7) mol/Km but the ratio of S/W of membrane proteins was significantly changed by endothelin at 5×10~(-9) and 1×10~(-7) mol/L.Metallothinojneijn could attenuate this change and protect membrane proteins form endothelin.

Key words: Endothelin;Metallothionein;Erythrocyte membrpe;ESR spin labelling

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Citing This Article：

Wang Gang, Hou Lin, Cheng Shi, Tang Chaoshu, An Rongshu. The protective effects of metallothionein on membrane proteins against endothelin: electron paramagnetic resonance spin labelling study. Acta Physiol Sin 1994; 46 (1): (in Chinese with English abstract).