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Modelling and analysis of interactions of flecainide with cardiac sodium channels

Wu Yuejin

Dept. Pharmacol., Guangdong Med. Coll.

Abstract

Model-predicted apparent raes of onset of flecainide blocking were 0.586, 0.128, 0.071, 0.030AP~(-1) respectively at stimulation frequencies of 0.1,0.5, 1.0, 2.0, and 3.3 Hz. The estimated time constant of recovery from block byt flecainide was 17,45 s. Analysis of gate-related receptor showed that the binding and unbinding of flecainide are modulated by activation process.

Key words: Flecainide;Antiarrhythmic agents;Sodium channel;Computer simulation;Gate-relat-ed receptor

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Citing This Article：

Wu Yuejin. Modelling and analysis of interactions of flecainide with cardiac sodium channels. Acta Physiol Sin 1994; 46 (1): (in Chinese with English abstract).