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Effects of lowing perilymph calcium concentration on various cochlear potentials

Wang Jian, Dong Weijia, Chen Jisheng, Liu Jianling

Hearing Research Laboratory, Nanjing Railway Medical College. Nanjing,Jiangsu；China(210009)

Abstract

Changes in compound action potentials of auditory nerve(CAP), cochlear microphonics(CM) and endocochlear potentials were observed when the calcium concentration of perilymph was reduced by means of perilymph perfusion, with the aim of analyzing how calcium was involved. Perfusion with Cd~(2+)-free artificial perilymph reversibly suppressed both CAP and CM amplitudes, but did not a ter the basic nonlinear propertres of CAP I/O curve. Furthermore, the perfusion did not alter the EP and negative EP (n-EP) induced by anoxia but eliminated the fast change of EP with respect to turning on and off of intense sound. The mechanisms underlying the effects of calcium are discussed.

Key words: Calcium;ECochG;Endocochlear potential;Perilymph perfusion

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Citing This Article：

Wang Jian, Dong Weijia, Chen Jisheng, Liu Jianling. Effects of lowing perilymph calcium concentration on various cochlear potentials. Acta Physiol Sin 1994; 46 (4): (in Chinese with English abstract).