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The role of brain cholinergic system in renal sodium, potassium and water excretion in rats

Jiang Chunling, Lin Maozhang

Department of Physiology, Dalian Medical University. Dalian,Liaoning

Abstract

In anesthetized rats intracerebroventricular(i.c.v.)injection of cholinergic agonist carbachol induced significant natriuresis, kaliuresis and diuresis(P<0.05). Among them, the degree of natriuresis was changed with carbachol in a dose-dependent manner(r=0.9997, P<0.05). These responses were completely blocked by cholinergic M receptor antagonist atropine or N receptor antagonist hexamethonium pretreatment. Such effects of carbachol were inhibited in part by pretreatment with adrenergic alpha receptor antagonist phentolamine. These results indicate that the natriuresis, kaliuresis and diuresis induced by i.c.v. injection of carbachol were primarily mediated by both muscarinic and nicotinic receptors in the brain, while the effect was in part mediated secondarily via adrenergic alpha receptor.

Key words: Natriuresis;Kaliuresis;Diuresis;Cholinergic M receptors;Cholinergic N remptors;Cholinergic agonist

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Citing This Article：

Jiang Chunling, Lin Maozhang. The role of brain cholinergic system in renal sodium, potassium and water excretion in rats. Acta Physiol Sin 1994; 46 (4): (in Chinese with English abstract).