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Effects of lateral harbenular stimulation on nociceptive response of neurons in rat spinal dorsal horn

Zhang Yihong, Cheng Zhenfeng

Department of Physiology, Xi^an Medical University. Xi^an.Shaanxi

Abstract

Ipsilateral stimulation of the LHb produced a significant attenuation of nociceptive response of wide dynamic range (WDR) neurons in the rat spinal dorsal horn. The inhibitory effect produced by LHb stimulation was partially blocked by systemic cyproheptadine and phentolamine but not naloxone. No significant change was observed in the activity of WDR neurons after ipsilateral electrolytical lesions of the LHb. These results suggest that the LHb participates in the supraspinal descending control on nociceptive response of WDR neurons in the spinal dorsal horn. However, tonic inhibitory mechanism seems not to be involved.

Key words: Lateral habenularnucleus;Spinal dorsal horn;Wide dynamic range neuron

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Citing This Article：

Zhang Yihong, Cheng Zhenfeng. Effects of lateral harbenular stimulation on nociceptive response of neurons in rat spinal dorsal horn. Acta Physiol Sin 1994; 46 (4): (in Chinese with English abstract).