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An improved quantitative method for evaluating neurological deficits in mice with focal cerebral ischemia

Wei Erqing, Zhu Chaoyang, Xu Qiuqin, Yu Yueping, Zhu Yefei, Zheng Minzhi

Department of harmacology,School of Medicine,Zhejiang University.Hangzhou 310031,Zhejiang

Abstract

We found that the variables measured by both quantitative and typical behavioral methods significantly changed in the ischemic mice, and correlated with the infarct volumes and neuron densities. The quantitative variables well correlated with those of typical behavioral assessment, too. ONO-1078 inhibited ischemic injury and reduced the total scrores of quantitative assessment. Thus, the quantitative method we developed is useful in evaluating neurological deficits of focal cerebral ischemia with the advantages of objectivity, quantification, simplicity and non-invasion, and can be used in the evaluation of neuroprotective effects of drugs.

Key words: Nneurobiology;Focal cerebral ischemia;Neurological examination;Hemiparesis;Mouse;{pranlukast，4-oxo-8-[p-(4-phenylbutyloxy) benzoylamino〕-2-(tetrazol-5-yl)-4H-1-benzopyran hem ihydrate};(ONO-1078)

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Citing This Article：

Wei Erqing, Zhu Chaoyang, Xu Qiuqin, Yu Yueping, Zhu Yefei, Zheng Minzhi. An improved quantitative method for evaluating neurological deficits in mice with focal cerebral ischemia. Acta Physiol Sin 2003; 55 (6): (in Chinese with English abstract).