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Animal models of schizophrenia using different laboratory mouse strains

Wu Jinhua, Zou Hong, Yu Jun, Zhou Xuedong, Xie Qinglian, Jin Meilei

Shanghai Research Center of Biotechnology,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences.Shanghai 200233

Abstract

These results show that MK801 induces schizophrenia-like symptoms in both inbred and outbred mice. Risperidone, an atypical antipsychotic drug for treating schizophrenia in human, was used in the schizophrenia models using BALB/c and C57BL/6 mice. The results indicated that risperidone dose-dependently inhibited the MK801-induced schizophrenia-like symptoms in BALB/c and C57BL/6 mice. Thus, our results indicate that the MK801-induced behaviors may serve as useful mouse models of schizophrenia.

Key words: Schizophrenia;Animal model;MK801;Hyperlocomotion;Stereotypy;Risperidone

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Citing This Article：

Wu Jinhua, Zou Hong, Yu Jun, Zhou Xuedong, Xie Qinglian, Jin Meilei. Animal models of schizophrenia using different laboratory mouse strains. Acta Physiol Sin 2003; 55 (4): (in Chinese with English abstract).