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Melatonin decreases the release of amino acid transmitters in hypoxic rat cortical slice

Gu Jing, Li Xuejun, Sun Fengyan

National Key Laboratory of Medical Neurobiology,Department of Neurobiology,Shanghai Medical University.Shanghai 200032

Abstract

The results showed that the contents of amino acids, including aspartate, glutamate, glutamine, glycine, taurine and GABA, in the medium were significantly increased to 240.4%, 334.3%, 200.6%, 210.4%, 168.6% and 263.9%, respectively (P<0.01 vs control) by 30 min hypoxic incubation. Melatonin can significantly reduce the increase of aspartate and glutamate, to 55.1% and 57.0% of the hypoxic group.

Key words: Melatonin;Hypoxia;Brain slice;Excitatory amino acids

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Citing This Article：

Gu Jing, Li Xuejun, Sun Fengyan. Melatonin decreases the release of amino acid transmitters in hypoxic rat cortical slice. Acta Physiol Sin 1999; 51 (4): (in Chinese with English abstract).