Issue Archive

Vasoactive intestinal peptide and epidermal growth factor upregulates bcl-2 gene expression in bronchial epithelial cells

Qin Xiaoqun, Sun Xiuhong, Luo Ziqiang

Department of Physiology,Hunan Medical University.Changsha 410078,Hunan

Abstract

Expression of protooncogenes bcl-2 and c-myc in cultured rabbit bronchial epithelial cell (BEC) was investigated in order to shed some light on genetic mechanisms underlying the protective antioxidant effect of pulmonary regulatory peptides, vasoactive intestinal peptide (VIP) and epidermal growth factor (EGF). Effects of these peptides and heat stress (HS) on expression of these genes were also studied.

Key words: Bronchial epithelial cell;bcl-2 gene;c-myc gene;Epidermal growth factor;Vasoactive intestinal peptide

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Qin Xiaoqun, Sun Xiuhong, Luo Ziqiang. Vasoactive intestinal peptide and epidermal growth factor upregulates bcl-2 gene expression in bronchial epithelial cells. Acta Physiol Sin 1999; 51 (4): (in Chinese with English abstract).