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Changes in vasopressin V_(1) receptor mRNA level in rats with high blood pressure induced by chronic stress

Lu Limin, Wang Jun, Yao Tai

Department of Physiology,Shanghai Medical University.Shanghai 200032；China

Abstract

Using reverse transcription polymerase chain reaction (RT-PCR) combined with Southern blotting hybridization technique, the AVP V_(1) receptor mRNA was found to be widely distributed in central neuronal system and other tissues of rats, such as cerebral cortex, hypothalamus, medulla, liver and kidney. The receptor mRNA levels in the cortex, hypothalamus and medulla were decreased significantly in chronically stressed rats, as compared with normal controls. But no significant change was observed in tissues of heart, liver and kidney.

Key words: vasopressin V_(1) receptor;Stress;Hypertension

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Citing This Article：

Lu Limin, Wang Jun, Yao Tai. Changes in vasopressin V_(1) receptor mRNA level in rats with high blood pressure induced by chronic stress. Acta Physiol Sin 1999; 51 (4): (in Chinese with English abstract).