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#beta#-endorphin involved in the regulation of humoral immune function of rats during acute hypoxia

Bai Haibo, Du Jizeng, Zhang Xiaoxiang

Department of Biological Science and Medical Engineering,Zhejiang University.Hangzhou 310027,Zhejiang；China

Abstract

It was found that after rats received icv injection of #beta#-endorphin (1ng/rat), the T-lymphocyte DNA content, the hemolysin-forming capacity of SRBC-sensitized rats and the IgG level were reduced significantly compared with the control (icv normal saline). Similar suppressive effects on immune function could be found after rats were exposed to 7 km altitude in a hypobaric chamber for 48 h. Pretreatment with icv injection of naltrexone, the immunosuppressive effects of acute hypoxia were partially blocked. Icv administration of #beta#-endorphin produced an increased in splenic cathcholamines, similar to those of hypoxia treated group.

Key words: Hypoxia;Immunofunction;#beta#-endorphin;Immunoregulation

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Citing This Article：

Bai Haibo, Du Jizeng, Zhang Xiaoxiang. #beta#-endorphin involved in the regulation of humoral immune function of rats during acute hypoxia. Acta Physiol Sin 1999; 51 (3): (in Chinese with English abstract).