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The role of endogenous CO in the regulation of endothelin-induced VSMC proliferation and MAPK activity

Ou Hesheng, Yan Limei, Fu Mingui, Wang Xiaohong, Pang Yongzheng, Su Jingyi, Tang Chaoshu

Institute of Vascular Research,the First Clinical Hospital,Beijing Medical University.Beijing 100034

Abstract

This study demonstrated that up-regulation of VSMC endogenous HO represents a cellular protective response to stress or injury. Inhibition of HO may enhance VSMC proliferation induced by ET-1 in vitro, suggesting that endogenous HO/CO system may be directly involved in the regulation of VSMC proliferation through MAPK signaling pathway.

Key words: Heme oxygenase;Carbon monoxide;Mitogen activated protein kinase;Vascular smooth muscle cell proliferation

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Citing This Article：

Ou Hesheng, Yan Limei, Fu Mingui, Wang Xiaohong, Pang Yongzheng, Su Jingyi, Tang Chaoshu. The role of endogenous CO in the regulation of endothelin-induced VSMC proliferation and MAPK activity. Acta Physiol Sin 1999; 51 (3): (in Chinese with English abstract).