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Effects of monocarboxylic acid derivatives on cardiac ventricular CFTR Cl~(-) channels in guinea pig

Zhou Shesheng, Zang Yimin

Department of Physiology,Fourth Military Medical University.Xi^an 710032,Shaanxi

Abstract

Using the whole-cell recording technique, the effects of monocarboxylic acid derivatives on cystic fibrosis transmembrane conductance regulator (CFTR) Cl~(-)-channel were examined in guinea pig ventricular myocytes. It is concluded that these monocarboxylic acid derivaties have different binding sites in cardiac ventricular myocytes, which might partially account for the varied effects in blocking anion channels.

Key words: Isoproterenol;Chloride channel blocker;Ventricular myocyte;Guinea pig

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Citing This Article：

Zhou Shesheng, Zang Yimin. Effects of monocarboxylic acid derivatives on cardiac ventricular CFTR Cl~(-) channels in guinea pig. Acta Physiol Sin 1999; 51 (3): (in Chinese with English abstract).