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An electrophysiological analysis of pathways from lateral septum to hippocampal CA1 area in rat

Jie Xiaping, Wang Fuzhuang

Inst. Bas. Med. Sci., Acad. Mil. Med. Sci.

Abstract

Upon stimulating the lateral septal region, a population spike could be recorded in the stratum pyramidale of hippocampal CAl together with a recordable EPSP in the apical dendrites (stratum radiatum). After destruction of hippocampal CA3. CA4 pyramidal cells by intraventricular microinjection of kainic acid, electrical stimulation of the lateral septum could no longer evoke EPSP in the apical dendrites. This experiment suggests that the neural connection of the lateral septo-CAl apical dendrites in mediated by the collaterals of the ipsilateral CA3 pyramidal cells. But after the destruction of CA3, CA4, electric stimulation of lateral septum could still evoke EPSP in the basal dendrites.

Key words: Septum;Hippocampus;Field potential;Kainic acid

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Citing This Article：

Jie Xiaping, Wang Fuzhuang. An electrophysiological analysis of pathways from lateral septum to hippocampal CA1 area in rat. Acta Physiol Sin 1991; 43 (2): (in Chinese with English abstract).