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Involvement of solitary tract nucleus in analgesic effect produced by paraventricular nucleus stimulation

Jiang Xinghong, Yu Guangdi, Yin Qizhang

Lab. Neurobiol., Suzhou Med. Coll.

Abstract

Electrical stimulation of the PVN could significantly enhance the pain threshold and increase the content of AVP in brainstem measured by radioimmunoassay. Solitary tract nucleus (STN) lesion could eliminate the analgesic effect induced by PVN stimulation. Intranuclear microinjection of AVP-antagonist and AVP-antiserum into the STN could block the analgesic effect of PVN stimulation. Intranuclear microinjection of AVP into the STN could mimick the analgesic effect similar to that of PVN stimulation. Electrical stimulation of the PVN could produce an analgesic effect. This effect might be mediated by the activation of VP-ergic neurons in PVN and upon releasing VPfrom the descending fibers, the activities of neurons in the STN are influenced.

Key words: Hypothalamic paraventricular nucleus;Solitary tract nucleus;Vasopressin;Analgesis;Vasopressin-antiserum;Vasopressin-antagonist;Radioimmunoassay

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Citing This Article：

Jiang Xinghong, Yu Guangdi, Yin Qizhang. Involvement of solitary tract nucleus in analgesic effect produced by paraventricular nucleus stimulation. Acta Physiol Sin 1991; 43 (2): (in Chinese with English abstract).