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Effects of stimulation of locus coeruleus on cardiac contractility and renal nerve activity

Wang Jianli, Fu Weijun, Chen Zhoudao, Lu Zhendong

Dept. Physiol., 2d Mil. Med. Univ.

Abstract

Experiments were performed on 64 cats anesthetized with chloralose- urethane, paralyzed and artificially ventilated. Electrical stimulation of locus coeruleus (LC) elicited increases in BP, HR, LVSP, de/dt max and RNA. Injection of L-glutamate into LC, could decrease BP, HR, LVSP and dp/dt max. The pressor response induced by electrical stimulation of LC might be mediated by the fibers passing through LC, while activation of LC neurons themselves would result in the depressor response.

Key words: Locus coeruleus;Blood pressure;Cardiac contractility;Renal nerve activity;L-glutamate;Kainic acid

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Citing This Article：

Wang Jianli, Fu Weijun, Chen Zhoudao, Lu Zhendong. Effects of stimulation of locus coeruleus on cardiac contractility and renal nerve activity. Acta Physiol Sin 1991; 43 (2): (in Chinese with English abstract).