Issue Archive

Spinal mechanism of the inhibitory effect of somatic input on the cardiac ischemia induced by hypothalamus stimulation

Zhu Weijian, Zhang Rongbao

Dept. Physiol., Zhejiang Med. Univ.

Abstract

Median nerve (MN) or deep peroneal nerve(DPN) stimulation could inhibit completely or partially the deflection of ischemic ECG ST segment due to stimulation of dorsomedial hypothalamic nucleus (DMH). The inhibitory effect of MN stimulation was more marked than that of DPN stimulation. Intrathecal injection (ith) of morphine (40#mu#g) could also have the effect. After ith naloxone (20 #mu#g), this effect was abolished. In intact rabbits, it was demonstrated that L-enkephalin (LENK) immunoreactive material was increased in the left or right intermediolateral cell column (IML) of T2-5 spinal cord after stimulation of left MN or DPN for five minutes. In the Cl transected rabbits, stimulation of MN only increased ipsilateral LENK immunoreactive material content in the thoracic IML, while stimulation of DPN produced no such an effect. These results indicate that stimulation of MN or DPN can inhibit cardiac ischemia induced by DMH stimulation and that the effect of MN stimulation is more potent.

Key words: Dersomedial hypothalamic nucleus;Somatic input;L-enkephalin;Myocardial ischemia;Intermediolateral cell column

Received: 　　Accepted:

Corresponding author: 　　E-mail:

Citing This Article：

Zhu Weijian, Zhang Rongbao. Spinal mechanism of the inhibitory effect of somatic input on the cardiac ischemia induced by hypothalamus stimulation. Acta Physiol Sin 1991; 43 (2): (in Chinese with English abstract).