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Renal responses to left atrial stretch in the cat

Sun Xiaolu, Wang Zhian, He Ruirong

Inst. Bas. Med., Hebei Med. Coll.

Abstract

Left atrial streth (LAS) resulted in a marked increase in UV, U sub(Na)V and U sub(K)V (all P<0.001) in the intact animals. Although LAS still caused an increase in UV and U sub(Na)V (P<0.01) after vagotomy, the increments were significantly less than those in vagi intact animals (P<0.005). LAS also induced an increase in UV, U sub(Na)V and U sub(K)V (P<0.05) in the vagi intact cats with heparin infusion (10U/min/kg), but the increments were significantly less than those in the cats without heparin (P<0.05). The responses to LAS were abolished by infusion of heparin after vagotomy (P>0.05). Following left renal denervation, theresponses to LAS remained unchanged in the innervated kidney, while those in denervated kidney were attenuated, though still significant. The difference in the response between the innervated and the denervated kidneys was statistically significant (P<0.05). These results indicate that LAS can induce a marked increase in UV, Usub(Na)V and U sub(K)V in anesthetized cats through both neural and humoral mechanisms.

Key words: Atrial stretch;Atrial volume receptor;Renal nerve;Vagus;Atrial natriuretic factor;Heparin

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Citing This Article：

Sun Xiaolu, Wang Zhian, He Ruirong. Renal responses to left atrial stretch in the cat. Acta Physiol Sin 1991; 43 (2): (in Chinese with English abstract).