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The interaction between nucleus accumbens and amygdala in accelerating the release of enkephalins and #beta#-endorphin

Ma Qingping, Han Jisheng

Neurosci. Res. Ctr, Beijing Med. Univ.

Abstract

Microninjection of morphine 20 #mu#g into nucleus accumbens increased the immunoreactive (ir) enkephalin content in amygdala perfusate and ir-#beta#-endorphin content. On the other hand, microinjection of morphine into amygdala increased the release of ir-enkephalins and ir-#beta#-endophin in the perfusates of N. accumbens. The results indicate the existence of reciprocal reinforcement of opioid release between the two nuclei, which may take part in a putative positive feedback mechanism in the cerebral analgesic system.

Key words: Nucleus accumbens;Amygdala;Morphine;Enkephalins;#beta#-endorphin

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Citing This Article：

Ma Qingping, Han Jisheng. The interaction between nucleus accumbens and amygdala in accelerating the release of enkephalins and #beta#-endorphin. Acta Physiol Sin 1991; 43 (2): (in Chinese with English abstract).