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Effect of #alpha#-human atrial natriuretic factor on isolated myocardial contractile force and action potential duration in guinea pig

Wu Weijian, Xia Qiang

Sect. Physiol., Zhoushan Hlth Sch., Zhejiang；Dept. Physiol., Zhejiang Med. Univ.

Abstract

At the level of 20 nmol/L and 40 nmol/L #alpha#-hANF, the contraction amplitude and rate of contraction phase decreased to a remarkable extent. And at 40 nmol/L, APDs were shortened significantly 20 nim after #alpha#-hANF. The results suggest that there exists a direct inhibitory effect of #alpha# -hANF on myocardial contractile force and action potential duration.

Key words: #alpha#-human atrial natriuretic factor;Contractile force;Action potential duration;Myocardium

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Citing This Article：

Wu Weijian, Xia Qiang. Effect of #alpha#-human atrial natriuretic factor on isolated myocardial contractile force and action potential duration in guinea pig. Acta Physiol Sin 1991; 43 (2): (in Chinese with English abstract).