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择时抗阻联合有氧运动对男青年颈总动脉弹性与血流动力学的影响

焦淼鑫^1,2, 申冰一², 刘海斌³, 陈丽红⁴, 杨光锐^1,*

¹上海健康医学院基础医学院，上海 201318；²大连理工大学生物工程学院，大连 116024；³大连理工大学体育与健康学院， 大连 116024；⁴华东师范大学医学与健康研究院，上海 200241

摘要

本研究旨在探讨择时抗阻联合有氧运动对男青年颈总动脉弹性与血流动力学影响。24名健康男青年(21.96 ± 0.43岁)分别在6 点、8 点、10 点、12 点、14 点、16 点、18 点、20 点开始单次急性抗阻联合有氧运动干预，测量运动前、运动后即刻、运动后10 min 和20 min 的颈总动脉轴心流速和管径波形，采用经典血流动力学理论计算血流动力学指标。结果显示：运动恢复期间，8 点运动的收缩压和平均压下降更明显(P < 0.05)；运动后20 min，6 点运动的动脉硬度指数和压力-应变弹性模量与静息状态相比减少，但20 点运动以上2 个指标显著升高(P < 0.05)。运动后即刻，6 点运动的升压幅度更高，20 点运动的壁面剪切应力平均值更高(P < 0.05)。上述结果提示，择时抗阻联合有氧运动对男青年血流动力学产生的影响不同。8 点单次急性抗阻联合有氧运动的降压效果更为明显；6 点运动有助于改善动脉弹性，但运动后即刻的血压增幅过大，因此不建议具有心血管疾病隐患的男性青年在此时间段运动；20 点运动对改善壁面剪切应力更有效，但伴随着动脉硬度指数和压力-应变弹性模量升高。本研究通过探讨颈总动脉弹性与血流动力学相关指标，为健康男青年选择运动时间段提供了科学依据。

关键词： 择时运动; 联合运动; 生物钟; 血流动力学; 颈总动脉

Effects of resistance combined with aerobic chrono-exercise on common carotid artery elasticity and hemodynamics in young men

JIAO Miao-Xin^1,2, SHEN Bing-Yi², LIU Hai-Bin³, CHEN Li-Hong⁴, YANG Guang-Rui^1,*

¹School of Basic Medical Sciences, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China；²School of Bioengineering, Dalian University of Technology, Dalian 116024, China；³School of Sport and Health Sciences, Dalian University of Technology, Dalian 116024, China；⁴Health Science Center, East China Normal University, Shanghai 200241, China

Abstract

The purpose of the present study was to investigate the effects of resistance combined with aerobic chrono-exercise on the common carotid artery elasticity and hemodynamics. 24 healthy young men (21.96±0.43 years old) underwent a single acute resistance combined with aerobic exercise intervention at eight time periods (6, 8, 10, 12, 14, 16, 18, and 20 o'clock). The axial flow velocity and diameter waveforms of the common carotid artery were measured, and the hemodynamics were calculated using the classical hemodynamic theory before exercise, immediately after exercise, 10 min and 20 min after exercise. The results showed that during exercise recovery, systolic and mean pressures decreased more markedly after exercise at 8 o'clock (P < 0.05); At 20 min post-exercise, arterial stiffness index and pressure-strain elastic modulus after exercise at 6 o'clock were reduced compared with the resting state, but were significantly elevated after exercise at 20 o'clock (P < 0.05). Immediately after exercise, the pressure rise was higher after exercise at 6 o'clock and the mean wall shear stress was higher after exercise at 20 o'clock (P < 0.05). These results suggest that resistance combined with aerobic chrono-exercise produces different effects on common carotid artery hemodynamics in young men. A single acute session of resistance combined with aerobic exercise at 8 o'clock is more effective in lowering blood pressure. Exercise at 6 o'clock is beneficial to improve arterial elasticity but is not recommended for young male individuals with cardiovascular disease risks because of the excessive increase in blood pressure immediately after exercise. Exercise at 20 o'clock is more effective in improving wall shear stress but is accompanied by elevated arterial stiffness indices and pressure-strain elastic modulus. These results provide a scientific basis for healthy young men in choosing the time of exercise by exploring the common carotid artery elasticity and hemodynamic-related indices.

Key words: chrono-exercise; combined exercise; biological clock; hemodynamics; common carotid artery

收稿日期：　　录用日期：

通讯作者：杨光锐　　E-mail:

DOI: 10.13294/j.aps.2025.0026

引用本文：

焦淼鑫, 申冰一, 刘海斌, 陈丽红, 杨光锐. 择时抗阻联合有氧运动对男青年颈总动脉弹性与血流动力学的影响[J]. 生理学报 2025; 77 (4): 741-751.

JIAO Miao-Xin, SHEN Bing-Yi, LIU Hai-Bin, CHEN Li-Hong, YANG Guang-Rui. Effects of resistance combined with aerobic chrono-exercise on common carotid artery elasticity and hemodynamics in young men. Acta Physiol Sin 2025; 77 (4): 741-751 (in Chinese with English abstract).