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肠道菌群及其代谢产物在幼年特发性关节炎中作用的研究进展

彭奥辉^1,2, 陈佑甲¹, 顾锦瑄¹, 金志刚^1,*, 钱旭波²

¹浙江师范大学生命科学学院，金华 321004；²金华市妇幼保健院，金华 321000

摘要

幼年特发性关节炎(juvenile idiopathic arthritis, JIA)是儿童中最常见的一种慢性风湿性疾病。JIA为自身免疫或自身炎症性疾病，具体发病机制未明，且治疗效果有限。近来研究发现，JIA患者体内存在肠道菌群及其代谢产物改变，其与JIA的发生与发展有关。本文将重点关注近年来肠道菌群及其代谢产物对免疫功能、肠道黏膜屏障的影响和肠-关节轴在JIA发病机制中的关键作用，并介绍基于肠道菌群及其代谢产物的潜在治疗方法。本文对JIA发病机制的深入探讨有利于挖掘JIA的潜在治疗靶点，进而为制定JIA防治策略提供新思路。

关键词： 幼年特发性关节炎; 肠道菌群; 短链脂肪酸; 黏膜屏障; 肠-关节轴

Research advance on the role of gut microbiota and its metabolites in juvenile idiopathic arthritis

PENG Ao-Hui^1,2, CHEN You-Jia¹, GU Jin-Xuan¹, JIN Zhi-Gang^1,*, QIAN Xu-Bo²

¹College of Life Sciences, Zhejiang Normal University, Jinhua 321004, China；²Jinhua Maternal & Child Health Care Hospital, Jinhua 321000, China

Abstract

Juvenile idiopathic arthritis (JIA) is the most common condition of chronic rheumatic disease in children. JIA is an autoimmune or autoinflammatory disease, with unclear mechanism and limited treatment efficacy. Recent studies have found a number of alterations in gut microbiota and its metabolites in children with JIA, which are related to the development and progression of JIA. This review focuses on the influence of the gut microbiota and its metabolites on immune function and the intestinal mucosal barrier and discuss the key role of the gut-joint axis in the pathogenesis of JIA and emerging treatment methods based on gut microbiota and its metabolites. This review could help elucidate the pathogenesis of JIA and identify the potential therapeutic targets for the prevention and treatment of JIA.

Key words: juvenile idiopathic arthritis; gut microbiota; short-chain fatty acid; mucosal barrier; gut-joint axis

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通讯作者：金志刚　　E-mail:

DOI: 10.13294/j.aps.2025.0040

引用本文：

彭奥辉, 陈佑甲, 顾锦瑄, 金志刚, 钱旭波. 肠道菌群及其代谢产物在幼年特发性关节炎中作用的研究进展[J]. 生理学报 2025; 77 (3): 587-601.

PENG Ao-Hui, CHEN You-Jia, GU Jin-Xuan, JIN Zhi-Gang, QIAN Xu-Bo. Research advance on the role of gut microbiota and its metabolites in juvenile idiopathic arthritis. Acta Physiol Sin 2025; 77 (3): 587-601 (in Chinese with English abstract).