当期文章

不同细胞Rap1对动脉粥样硬化的差异性调控作用

宋珊杉¹, 杨惠茹¹, 易小莉¹, 余军², 许传铭^1,*

¹江西中医药大学医学转化中心，南昌 330004；²天普大学Lewis Katz 医学院代谢疾病研究中心和生理学系，费城 19140，美国

摘要

心血管疾病是导致死亡的主要原因，该类疾病发病率高，对人类健康构成重大威胁。动脉粥样硬化是一种慢性炎症性疾病，同时也是大多数心血管疾病的主要病理基础。动脉粥样硬化的发病率持续上升，但其发病机制尚未完全阐明。小GTP酶Rap1 (Ras-association proximate 1)作为小G蛋白超家族成员，是细胞中重要的分子开关，参与调控细胞的分化、增殖和黏附等生理功能。Rap1通过在Rap1-GTP和Rap1-GDP之间循环来实现分子开关的效用。Rap1以细胞差异性的方式参与调控动脉粥样硬化的发生、发展过程。本文总结了不同细胞Rap1在动脉粥样硬化发生、发展中的作用及机制，旨在为动脉粥样硬化的治疗提供新标靶和新思路。

关键词： 动脉粥样硬化; Rap1; 内皮细胞; 巨噬细胞; 平滑肌细胞

Cellular differential impact of the Rap1 on atherosclerosis

SONG Shan-Shan¹, YANG Hui-Ru¹, YI Xiao-Li¹, YU Jun², XU Chuan-Ming^1,*

¹Translational Medicine Centre, Jiangxi University of Chinese Medicine, Nanchang 330004, China；²Center for Metabolic Disease Research and Department of Physiology, Lewis Katz School of Medicine, Temple University, Philadelphia 19140, USA

Abstract

Cardiovascular diseases are the leading cause of mortality, posing a significant threat to human health due to the high incidence rate. Atherosclerosis, a chronic inflammatory disease, serves as the primary pathological basis for most such conditions. The incidence of atherosclerosis continues to rise, but its pathogenesis has not been fully elucidated. As an important member of the small GTPase superfamily, Ras-association proximate 1 (Rap1) is an important molecular switch involved in the regulation of multiple physiological functions including cell differentiation, proliferation, and adhesion. Rap1 achieves the utility of the molecular switch by cycling between Rap1-GTP and Rap1-GDP. Rap1 may influence the occurrence and development of atherosclerosis in a cell-specific manner. This article summarizes the potential role and mechanism of Rap1 in the progression of atherosclerosis in different cells, aiming to provide new therapeutic targets and strategies for clinical intervention.

Key words: Atherosclerosis; Rap1; endothelial cell; Macrophage; vascular smooth muscle cell

收稿日期：　　录用日期：

通讯作者：许传铭　　E-mail:

DOI: 10.13294/j.aps.2025.0045

引用本文：

宋珊杉, 杨惠茹, 易小莉, 余军, 许传铭. 不同细胞Rap1对动脉粥样硬化的差异性调控作用[J]. 生理学报 2025; 77 (3): 483-492.

SONG Shan-Shan, YANG Hui-Ru, YI Xiao-Li, YU Jun, XU Chuan-Ming. Cellular differential impact of the Rap1 on atherosclerosis. Acta Physiol Sin 2025; 77 (3): 483-492 (in Chinese with English abstract).