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非小细胞肺癌患者免疫反应与肠道菌群、代谢重编程之间的关系

郭瑞¹, 何喆², 刘凡³, 彭会珍⁴, 邢利威^1,*

¹云南中医药大学第一临床医学院，昆明 650000；²云南中医药大学第二临床医学院，昆明 650000；³浙江中医药大学平阳中医院康复科，温州 325000；⁴云南中医药大学中药学院，昆明 650000

摘要

近年来许多研究表明肠道微生物失调(包括构成和功能的改变)可通过特定的途径影响肺组织的稳态，进而促进肺部疾病的易感性。肠道菌群及代谢物可调节免疫、炎症反应等作用，与肺癌的发生、发展以及免疫治疗效果联系紧密。非小细胞肺癌细胞在异常增殖过程中通过改变癌细胞自身的代谢方式获取更多的物质和能量，其中葡萄糖和氨基酸代谢重编程分别为肿瘤细胞提供大量ATP和碳源、氮源，为肿瘤细胞的增殖、侵袭和免疫逃逸提供最佳条件。本文综述了非小细胞肺癌患者免疫反应与肠道菌群、代谢重编程的相关性，同时讨论肠道菌群、代谢重编程影响非小细胞肺癌发生、发展及免疫治疗的潜在机制，以期为肺癌患者的精准治疗提供新思路。

关键词： 非小细胞肺癌; 代谢重编程; 肠道菌群; 免疫

Relationship of immune response with intestinal flora and metabolic reprogramming in patients with non-small cell lung cancer

GUO Rui¹, HE Zhe², LIU Fan³, PENG Hui-Zhen⁴, XING Li-Wei^1,*

¹The First Clinical Medical College, Yunnan University of Chinese Medicine, Kunming 650500, China；²The Second Clinical Medical College, Yunnan University of Chinese Medicine, Kunming 650500, China；³Department of Rehabilitation, Pingyang Hospital of Traditional Chinese Medicine, Zhejiang University of Chinese Medicine, Wenzhou 325000, China；⁴School of Chinese Materia Medica, Yunnan University of Chinese Medicine, Kunming 650500, China

Abstract

Numerous research conducted in recent years has revealed that gut microbial dysbiosis, such as modifications in composition and activity, might influence lung tissue homeostasis through specific pathways, thereby promoting susceptibility to lung diseases. The development and progression of lung cancer, as well as the effectiveness of immunotherapy are closely associated with gut flora and metabolites, which influence immunological and inflammatory responses. During abnormal proliferation, non-small cell lung cancer cells acquire more substances and energy by altering their own metabolic pathways. Glucose and amino acid metabolism reprogramming provide tumor cells with abundant ATP, carbon, and nitrogen sources, respectively, providing optimal conditions for tumor cell proliferation, invasion, and immune escape. This article reviews the relationship of immune response with gut flora and metabolic reprogramming in non-small cell lung cancer, and discusses the potential mechanisms by which gut flora and metabolic reprogramming affect the occurrence, development, and immunotherapy of non-small cell lung cancer, in order to provide new ideas for precision treatment of lung cancer patients.

Key words: non-small cell lung cancer; metabolic reprogramming; intestinal flora; immunity

收稿日期：　　录用日期：

通讯作者：邢利威　　E-mail:

DOI: 10.13294/j.aps.2025.0031

引用本文：

郭瑞, 何喆, 刘凡, 彭会珍, 邢利威. 非小细胞肺癌患者免疫反应与肠道菌群、代谢重编程之间的关系[J]. 生理学报 2025; 77 (2): 289-299.

GUO Rui, HE Zhe, LIU Fan, PENG Hui-Zhen, XING Li-Wei. Relationship of immune response with intestinal flora and metabolic reprogramming in patients with non-small cell lung cancer. Acta Physiol Sin 2025; 77 (2): 289-299