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靶向核因子E2相关因子2信号通路的抗衰老中药研究进展

徐嘉怡¹, 闫亮文¹, 唐慎康^1,2, 刘朋飞^1,*

¹西安交通大学第二附属医院生物诊断治疗国家地方联合工程研究中心，西安 710004；²陕西中医药大学附属医院肿瘤科，咸阳 712000

摘要

机体的氧化还原稳态失衡是衰老的主要特征，也是多种衰老相关疾病的主要发病机制。作为机体氧化还原稳态的调控中枢，转录因子核因子E2相关因子2 (nuclear factor erythroid 2-related factor 2, NRF2)可通过激活多种抗氧化酶的转录缓解氧化应激压力。我国是中药的发源地，也是世界中药材应用最广泛、药源最丰富的国家，从古至今，中药均在临床上广泛应用，其在抗衰老方面的应用也日渐被人们所接受。本文以NRF2信号通路为核心，总结了多种抗衰老中药与NRF2调节的相关性，并结合NRF2信号网络系统分析了中药在抗衰老过程中的共性关键机制。

关键词： 核因子E2相关因子2; 中药; 抗衰老; 中药单体

Traditional Chinese medicine used as anti-aging agent by targeting nuclear factor erythroid 2-related factor 2 signaling pathway

XU Jia-Yi¹, YAN Liang-Wen¹, TANG Shen-Kang^1,2, LIU Peng-Fei^1,*

¹National and Local Joint Engineering Research Center for Biological Diagnosis and Treatment, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China；²Department of Oncology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China

Abstract

The imbalance of redox homeostasis is a major characteristic of aging and contributes to the pathogenesis of various aging-related diseases. As a regulatory hub of redox homeostasis, nuclear factor erythroid 2-related factor 2 (NRF2) can attenuate oxidative stress by activating the transcription of many antioxidant enzymes. China is the birthplace of traditional Chinese medicine (TCM) which has been wildly used as medicine for thousands of years. Recently, TCM as anti-aging medicine has attracted enormous attention. Focusing on the NRF2 signaling pathway, this paper summarizes the correlation between various anti-aging TCM and the NRF2 signaling, and discusses the common key mechanisms by which TCM slows the aging process by targeting the NRF2 signaling network.

Key words: nuclear factor erythroid 2-related factor 2; Chinese medicine; anti-aging; herb monomer

收稿日期：　　录用日期：

通讯作者：刘朋飞　　E-mail: liupengfei@xjtu.edu.cn

DOI: 10.13294/j.aps.2023.0078

引用本文：

徐嘉怡, 闫亮文, 唐慎康, 刘朋飞. 靶向核因子E2相关因子2信号通路的抗衰老中药研究进展[J]. 生理学报 2023; 75 (6): 877-886.

XU Jia-Yi, YAN Liang-Wen, TANG Shen-Kang, LIU Peng-Fei. Traditional Chinese medicine used as anti-aging agent by targeting nuclear factor erythroid 2-related factor 2 signaling pathway. Acta Physiol Sin 2023; 75 (6): 877-886 (in Chinese with English abstract).