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IL-27：介导免疫相关疾病的新因子

张娜¹, 杨旸^1,2, 梁秋妍¹, 刁小芮¹, 衣雪洁^1,3, 常波^1,*

¹沈阳体育学院运动人体科学学院，沈阳 110115；²上海体育学院运动科学学院，上海 200438；³沈阳体育学院运动与健康研究中心，沈阳 110115

摘要

白细胞介素27 (interleukin 27, IL-27)是一种多效性的细胞因子，能参与调节机体的先天性和适应性免疫。以往研究显示它能介导体内多种炎症反应，随着动物模型和技术手段的发展，多项研究表明它与自身免疫性疾病及其他免疫相关疾病密切相关，并被认为是治疗病毒性疾病、自身免疫性疾病、肿瘤及肥胖的一个重要候选因子。因此本文就IL-27在艾滋病、类风湿关节炎、肿瘤及肥胖中的作用展开综述，旨在为免疫相关疾病的治疗提供新的思路。

关键词： 白细胞介素27; 艾滋病 ; 类风湿性关节炎; 肿瘤; 肥胖

IL-27: a novel cytokine mediating immune related diseases 

ZHANG Na¹, YANG Yang^1,2, LIANG Qiu-Yan¹, DIAO Xiao-Rui¹, YI Xue-Jie^1,3, CHANG Bo^1,*

¹School of Sports and Human Sciences, Shenyang Sport University, Shenyang 110115, China；²School of Sports and Human Sciences, Shanghai Sport University, Shanghai 200438, China；³Exercise and Health Research Center, Shenyang Sport University, Shenyang 110115, China

Abstract

Interleukin 27 (IL-27) is a pleiotropic cytokine that is involved in the regulation of the body’s innate and adaptive immunity. Previous studies have shown that IL-27 mediates a variety of inflammatory responses in vivo. With the development of animal models and technical tools, several studies have shown that it is also closely associated with autoimmune diseases and other immune related diseases, and is considered as an important candidate for the treatment of viral disease, autoimmune diseases, tumors and obesity. Therefore, this paper reviews recent progress on the role of IL-27 in acquired immunodeficiency syndrome (AIDS), rheumatoid arthritis, tumors and obesity, with the aim of providing new ideas for the treatment of immune related diseases. 

Key words: IL-27; AIDS; rheumatoid arthritis; tumor; obesity

收稿日期：　　录用日期：

通讯作者：常波　　E-mail: changbo8387@163.com

DOI: 10.13294/j.aps.2023.0020

引用本文：

张娜, 杨旸, 梁秋妍, 刁小芮, 衣雪洁, 常波. IL-27：介导免疫相关疾病的新因子[J]. 生理学报 2023; 75 (2): 303-315.

ZHANG Na, YANG Yang, LIANG Qiu-Yan, DIAO Xiao-Rui, YI Xue-Jie, CHANG Bo. IL-27: a novel cytokine mediating immune related diseases . Acta Physiol Sin 2023; 75 (2): 303-315 (in Chinese with English abstract).