过刊浏览

铁死亡在缺氧相关脑损伤中的研究进展

常熙雯^1,2, 赵安鹏^1,2, 姚菀腾^1,2, 李文斌¹, 王荣^1,2,*

¹中国人民解放军联勤保障部队第九四〇医院药剂科，兰州 730050；²兰州大学药学院，兰州 730000

摘要

脑部缺氧经常带来不可逆的中枢神经系统损伤，严重危害着人类健康，对缺氧相关脑损伤机制的深入探索具有重要意义。铁死亡作为一种程序性细胞死亡，主要表现为铁依赖性脂质过氧化物过量积累导致的细胞死亡，与谷胱甘肽代谢、脂质过氧化和铁代谢异常相关，参与多种疾病的发生和发展。研究发现铁死亡在缺氧相关脑损伤中发挥重要作用。本文总结了铁死亡的发生机制，并阐述了其在脑缺血再灌注损伤、新生儿缺氧缺血性脑损伤、阻塞性睡眠呼吸暂停所致脑损伤及高原低氧脑损伤中的研究进展。

关键词： 铁死亡; 高原低氧; 缺血再灌注; 新生儿缺氧缺血性脑损伤; 阻塞性睡眠呼吸暂停; 间歇性低氧

Research progress of ferroptosis in hypoxia-associated brain injury 

CHANG Xi-Wen^1,2, ZHAO An-Peng^1,2, YAO Wan-Teng^1,2, LI Wen-Bin¹, WANG Rong^1,2,*

¹Department of Pharmacy, The 940th Hospital of PLA Joint Logistics Support Force, Lanzhou 730050, China；²School of Pharmacy, Lanzhou University, Lanzhou 730000, China

Abstract

Cerebral hypoxia often brings irreversible damage to the central nervous system, which seriously endangers human health. It is of great significance to further explore the mechanism of hypoxia-associated brain injury. As a programmed cell death, ferroptosis mainly manifests as cell death caused by excessive accumulation of iron-dependent lipid peroxides. It is associated with abnormal glutathione metabolism, lipid peroxidation and iron metabolism, and is involved in the occurrence and development of various diseases. Studies have found that ferroptosis plays an important role in hypoxia-associated brain injury. This review summarizes the mechanism of ferroptosis, and describes its research progress in cerebral ischemia reperfusion injury, neonatal hypoxic-ischemic brain damage, obstructive sleep apnea-induced brain injury and high-altitude hypoxic brain injury.

Key words: ferroptosis; high-altitude hypoxia; ischemia-reperfusion; hypoxic-ischemic brain damage; obstructive sleep apnea; intermittent hypoxia

收稿日期：　　录用日期：

通讯作者：王荣　　E-mail: wangrong-69@163.com

DOI: 10.13294/j.aps.2023.0018

引用本文：

常熙雯, 赵安鹏, 姚菀腾, 李文斌, 王荣. 铁死亡在缺氧相关脑损伤中的研究进展[J]. 生理学报 2023; 75 (2): 255-268.

CHANG Xi-Wen, ZHAO An-Peng, YAO Wan-Teng, LI Wen-Bin, WANG Rong. Research progress of ferroptosis in hypoxia-associated brain injury . Acta Physiol Sin 2023; 75 (2): 255-268 (in Chinese with English abstract).