过刊浏览

脂肪源性外泌体在动脉粥样硬化病理进展中的作用

刘莲, 胡杭, 甘露^*

四川大学华西医院急诊医学研究室/急诊科，成都 610041

摘要

动脉粥样硬化是一种病因复杂的血管壁慢性炎症性疾病，近年来其发病率持续增高，肥胖和糖尿病是其公认的危险因素。脂肪组织作为机体内重要的代谢器官，同时亦具有强大的内分泌功能。在肥胖和糖尿病情况下，脂肪组织来源的多种细胞因子及外泌体介导了器官、细胞间的信息交流，参与多种疾病的发生和发展。外泌体作为细胞间重要的通讯媒介，调控多种心血管疾病病理进程，与动脉粥样硬化密切相关。本文围绕动脉粥样硬化病理进程中的内皮功能障碍、炎症反应、脂质代谢紊乱和胰岛素抵抗四个重要的病变过程，就脂肪源性外泌体的作用机制展开综述，以期为该疾病的研究和诊疗提供参考。

关键词： 动脉粥样硬化; 脂肪源性外泌体; 发病机制

The role of adipose-derived exosomes in the pathological progression of atherosclerosis

LIU Lian, HU Hang, GAN Lu^*

Laboratory of Emergency Medicine/Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu 610041, China

Abstract

Atherosclerosis is a chronic inflammatory disease of vascular walls with a complex etiology. In recent years, the incidence of atherosclerosis continues to increase with obesity and diabetes as major risk factors. As an important metabolic organ in the body, adipose tissue also has a powerful endocrine function. In the case of obesity and diabetes, various cytokines and exosomes derived from adipose tissue mediate organ-organ/cell-cell crosstalk, and are involved in the occurrence and development of various diseases. As an important intercellular communicator, exosomes regulate the pathological process of various cardiovascular diseases and are closely related to atherosclerosis. In this paper, we reviewed the mechanism of adipose-derived exosomes in atherosclerosis with focus on endothelial dysfunction, inflammatory response, lipid metabolism disorder and insulin resistance, hoping to provide reference for the research, diagnosis and treatment of atherosclerosis.

Key words: Atherosclerosis; adipose-derived exosomes; pathogenesis

收稿日期：　　录用日期：

通讯作者：甘露　　E-mail: ganlu@wchscu.cn

DOI: 10.13294/j.aps.2023.0032

引用本文：

刘莲, 胡杭, 甘露. 脂肪源性外泌体在动脉粥样硬化病理进展中的作用[J]. 生理学报 2023; 75 (2): 241-247.

LIU Lian, HU Hang, GAN Lu. The role of adipose-derived exosomes in the pathological progression of atherosclerosis. Acta Physiol Sin 2023; 75 (2): 241-247 (in Chinese with English abstract).