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成年人脂肪体重、去脂体重和肺通气功能的关系

冯逵, 陈莉, 祖淑玉, 韩少梅, 朱广瑾

中国医学科学院基础医学研究所、北京协和医学院基础学院 生理与病理生理学系； 流行病学与统计学系，北京 100005

摘要

本文旨在研究分析成年人去脂体重(fat free mass, FFM)、脂肪体重(fat mass, FM)和肺通气功能的关系。随机抽取黑龙江省部分地区19~81 岁健康成年人群1 307 人(男性372 人，女性935 人)，测量身高、体重，采用身体成分仪和肺功能仪分别检测FFM、FM 和肺通气功能，并采用Pearson 相关分析、独立样本t 检验和多元逐步回归等统计学方法分析FFM、FM 和肺通气功能的关系。结果显示，无论性别，年龄均与脂肪体重指数(FM index, FMI)呈正相关(P<0.001)，去脂体重指数(FFM index, FFMI)和用力肺活量(forced vital capacity, FVC)、用力呼气一秒量(forced expiratory volume in one second,FEV1)、最高呼气流量(peak expiratory flow, PEF)、用力呼出25% 肺活量时呼气流量(forced expiratory flow at 25% of forcedvital capacity, FEF25%)均呈正相关(P<0.01)，FMI 和FVC、FEV1、FEF75% 呈负相关(P<0.05)。男性FMI 和最大呼气中段流量(maximal mid-expiratory flow, MMEF)呈负相关(P<0.05)。无论性别，FFMI 对于FVC 作用大于FMI，而对于FEV1，男性FMI 作用大于FFMI，女性则反之。无论性别，FFMI 升高，PEF 和FEF2 5% 也升高，而FMI 对二者无作用。无论性别，FMI 升高，FEF7 5% 降低，而FFMI 对其无作用。FMI 升高，男性MMEF 降低，女性无明显改变。本研究结果表明，FFM 和FM 均是影响肺通气功能的独立因素，反映骨骼肌力的FFM 与肺通气功能呈正相关，FM 与肺通气功能呈负相关。FFM 和FM 对肺通气功能作用大小存在差别。

关键词： 身体成分; 用力呼气流量; 用力肺活量

分类号：R332

[Fat mass and fat free mass on ventilatory function in adults.] [Ariticle in Chinese]

FENG Kui, CHEN Li, ZU Shu-Yu, HAN Shao-Mei, ZHU Guang-Jin

Department of Physiology and Pathophysiology； Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China

Abstract

This study is designed to probe for the effects of fat mass (FM) and fat free mass (FFM) on ventilatory function in adults.1 307 healthy adults (372 males and 935 females) were selected from some localities of Heilongjiang province through random samplingby means of questionnaire and physical examination and measured for height, weight, waist to hip ratio (WHR), FM, FFM andventilatory function. The data were analyzed by means of Pearson correlation analysis, independent-samples t test and multi-factorsregression analysis. Regardless of sex, an independent positive correlation was found (P<0.001) between age and fat mass index (FMI).Regardless of sex, fat free mass index (FFMI) was found to be positively associated with forced vital capacity (FVC), forced expiratoryvolume in one second (FEV1), peak expiratory flow (PEF) and forced expiratory flow at 25% of forced vital capacity (FEF25%) (P<0.01), and FMI was significantly and negatively related to FVC, FEV1, FEF75% (P<0.05). In males FMI was significantly andnegatively related to maximal mid-expiratory flow (MMEF) (P<0.05). Regardless of sex, the effect of FFMI on FVC was higher thanthat of FMI. For the males, the effect of FFMI on FVC was smaller than that of FMI, while the opposite was found in the females.Regardless of sex, FEF75% tended to decrease with increasing FMI, while FFMI was found to have no effects on FEF75%. MMEFtended to decrease with increasing FMI in the males, but no marked change was found in the females. The above results suggest that FMand FFM are independent factors influencing ventilatory function in adults. FM is negatively correlated with ventilatory function, butas a reflection of muscle mass, FFM is positively correlated with ventilatory function in adults. There is quantitative difference between the effects of FFM and FM on ventilatory function.

Key words: body composition; forced expiratory flow rates; forced vital capacity

收稿日期：2009-11-13　　录用日期：2010-01-19

通讯作者：朱广瑾　　E-mail: zhugj@pumc.edu.cn

引用本文：

冯逵, 陈莉, 祖淑玉, 韩少梅, 朱广瑾. 成年人脂肪体重、去脂体重和肺通气功能的关系[J]. 生理学报 2010; 62 (2): 122-128.

FENG Kui, CHEN Li, ZU Shu-Yu, HAN Shao-Mei, ZHU Guang-Jin. [Fat mass and fat free mass on ventilatory function in adults.] [Ariticle in Chinese] . Acta Physiol Sin 2010; 62 (2): 122-128 (in Chinese with English abstract).