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蝎毒素与小电导钙激活钾通道独特的相互作用

杨帆, 陈宗运, 吴英亮

武汉大学生命科学学院，病毒学国家重点实验室，武汉 430072；湖北医药学院基础医学院生物化学和分子生物学系，医药大分子实验室，十堰 442000

摘要

分布在神经系统中的小电导Ca2+激活钾通道(small conductance Ca2+-activated potassium channels, SK通道)在学习、记忆及突触的可塑性过程中发挥了重要的作用。利用短链蝎毒素揭示了SK通道大部分药理学性质。不同于大部分电压门控钾通道和大电导Ca2+激活钾通道，SK通道电流仅能被少量蝎毒素抑制。近来，研究揭示了SK通道选择性识别毒素的结构基础是SK通道细胞外孔区部位存在一种新颖的多肽筛选器。本综述总结了蝎毒素与SK通道独特的相互作用，这不仅对深入研究SK通道生理功能具有重要的作用，而且有助于促进SK通道相关疾病的药物开发。

关键词： 蛋白-蛋白相互作用; 多肽筛选器; 钾通道; α-KTx

分类号：Q965.9;Q74

Unique interactions between scorpion toxins and small conductance Ca2+-activated potassium channels

Yang Fan, CHEN Zong-Yun, WU Ying-Liang

1State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China； 2Department of Biochemistry and Molecular Biology, Medicinal Macromolecular Laboratory, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan 442000, China

Abstract

Small conductance Ca2+-activated potassium channels (SK channels) distributing in the nervous system play an important role in learning, memory and synaptic plasticity. Most pharmacological properties of them are determined by short-chain scorpion toxins. Different from most voltage-gated potassium channels and large-conductance Ca2+-activated potassium channels, SK channels are only inhibited by a small quantity of scorpion toxins. Recently, a novel peptide screener in the extracellular pore entryway of SK channels was considered as the structural basis of toxin selective recognition. In this review, we summarized the unique interactions between scorpion toxins and SK channels, which is crucial not only in deep-researching for physiological function of SK channels, but also in developing drugs for SK channel-related diseases.

Key words: protein-protein interaction; peptide screener; potassium channel; α-KTx

收稿日期：2014-07-01　　录用日期：2014-08-26

通讯作者：陈宗运,吴英亮　　E-mail: ylwu@whu.edu.cn, chenzy2005@126.com

引用本文：

杨帆, 陈宗运, 吴英亮. 蝎毒素与小电导钙激活钾通道独特的相互作用[J]. 生理学报 2015; 67 (3): 255-260.

Yang Fan, CHEN Zong-Yun, WU Ying-Liang. Unique interactions between scorpion toxins and small conductance Ca2+-activated potassium channels. Acta Physiol Sin 2015; 67 (3): 255-260 (in Chinese with English abstract).