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手术截断小鼠尾末端诱发的痛觉过敏和吗啡镇痛效应

Susan J.KIM, 卓敏

多伦多大学医学院生理系,多伦多大学痛觉研究中心,安大略,多伦多,加拿大

摘要

手术截断小鼠尾末端可诱发长期性的痛觉过敏和吗啡镇痛效应变化.这种长期性的变化可能是由于中枢神经系统的神经可塑性变化引起的(从脊髓背角到皮层).在截尾5周后,小鼠后肢和余下的尾端出现痛敏反应.低剂量吗啡可诱发热板的易化反应.这些可塑性变化能延长至5周,因此小鼠的截尾模型可以用于研究截肢后的中枢性长期性的可塑性变化.

关键词： 截肢; 痛; 镇痛; 易化; 吗啡; 小鼠; 幻肢痛

Biphasic modulation of behavioral nociceptive responses by morphine in adult mice after amputation

Ma Aiqun

Department of Cardiology, the First Hospital, Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Xi'an Jiaotong University. Xi'an 710061, China

Abstract

Amputation of a segment of the tail produced long-lasting changes in nociception and morphine-induced antinociception.Plastic changes in nociceptive transmission may occur at the spinal cord as well as supraspinal structures after tail amputation. Acutehyperalgesia is detected at the remaining part of the tail as well as hindpaw. Morphine induced facilitation of the hot-plate (HP) responseat a low dose and a greater dose of morphine is required to produce complete inhibition of the HP response. Since these effects happen atfive weeks after the surgery, tail amputation may serve as a mouse model for studying long-term plastic changes in central nervous systemafter amputation.

Key words: Amputation;Nociception;Antinociception;Facilitation;Morphine;Mice;Phantom pain

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引用本文：

Susan J.KIM, 卓敏. 手术截断小鼠尾末端诱发的痛觉过敏和吗啡镇痛效应[J]. 生理学报 2004; 56 (4): .

Ma Aiqun. Biphasic modulation of behavioral nociceptive responses by morphine in adult mice after amputation. Acta Physiol Sin 2004; 56 (4): (in Chinese with English abstract).