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巯甲丙脯酸降低缺血再灌注心律失常的发生率

张敏, 潘敬运, 朱小南, 詹澄扬

江西九江医学专科学校. 江西, 九江；中山医科大学生理教研室. 广东, 广州 510089

摘要

在缺血再灌注组, 缺血再灌 注引起的心室纤颤发生率为78％; 在巯甲丙脯酸组, 巯 甲丙脯酸预处理可使缺血再灌注心室纤颤发生率下降了65.5％; 与缺血再灌注组相比, 巯 甲丙脯酸组的心肌儿茶酚胺含量、心肌6-酮-PGF_(1#alpha#)(6-keto-PGF_(1#alpha#))的含量明显升高(P<0.01), 血栓素B_(2)(T_(x)B_(2)的含量和TxB_(2)/6-keto-PGF_(1#alpha#)的比值则明显降低(P<0.01)。在AngⅡ组, Ang Ⅱ灌 流可逆转巯甲丙脯酸的保护作用, 使心室纤颤发生率升高至85％, 心肌儿茶酚胺的含量与缺血再灌注组无显著差异(P>0.05)。

关键词： 巯甲丙脯酸; 缺血再灌注; 心室纤颤; 儿茶酚胺; 血栓素A_(2); 前列环素

Reduction of incidence of ischemia-reperfusion induced ventricular fibrillation by captopril

Zhang Min, Pan Jingyun, Zhu Xiaonan, Zhan Chengyang

Jiujiang Medical School, Jiangxi Province. Jiujiang, Jiangxi； China

Abstract

Regional myocardial ischemia was induced by ligation of the left coronary artery followed by reperfusion. In the ischemia reperfusion group, ventricular fibrillation during reperfusion took place in 78% of the hearts. In the group pretreated with captopril, the incidence of ventricular fibrillation decreased significantly(65.5％). In comparision with the ischemia reperfusion group, myocardial catecholamine content and 6-keto-PGF_(1#alpha#) of the captopril group were significantly increased(P<0.01)while thromboxane B_(2)(TxB_(2)/6-keto-PGF_(1#alpha#) were decreased (P<0.01). In Ang Ⅱ group, infusion of angiotensin Ⅱ reversed the protective effect of captopril and restored the incidence of ventricular fibrillation (85％), while myocardial catecholamine content was not different from the ischemia reperfusion group (P>0.05).

Key words: Captopril;Ischemia-reperfusion;Ventricular fibrillation;Catecholamine; Thromboxane B_(2);Prostacyclin

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引用本文：

张敏, 潘敬运, 朱小南, 詹澄扬. 巯甲丙脯酸降低缺血再灌注心律失常的发生率[J]. 生理学报 1995; 47 (6): .

Zhang Min, Pan Jingyun, Zhu Xiaonan, Zhan Chengyang. Reduction of incidence of ischemia-reperfusion induced ventricular fibrillation by captopril. Acta Physiol Sin 1995; 47 (6): (in Chinese with English abstract).